Macrophage colony-stimulating factor 1 receptor (CSF1R)

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby has an important role in innate immunity and in inflammatory processes.

Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is needed for normal bone and tooth development. Required for normal male and female fertility, and also for normal development of milk ducts and acinar structures in the mammary gland during pregnancy.