This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Galectin-10 Antibodies
AND CLC ELISA kits, Galectin-10 Proteins
Many biological assays use antibodies to detect Galectin-10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Galectin-10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Galectin-10 antibodies...
Previous: CDH12
Next: CLCA1
CLC Infographic by Boster Bio
All CLC Products
Product
Figures
Specificity
Applications
Price
CLC Overview
Facts about Galectin-10.
Galectin-10 (CLC)
Allergic immune reactions through the recognition of cell-surface glycans. Critical for the anergy and suppressive role of CD25-positive regulatory T-cells (Treg).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLC |
| Uniprot: | Q05315 |
| Entrez: | 1178 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Charcot-Leyden crystal proteinLGALS10A; CLC; EC 3.1.1.5; eosinophil lysophospholipase; GAL10; Gal-10; galectin 10; Galectin10; Galectin-10; LGALS10; LPPL_HUMAN; Lysolecithin acylhydrolase; MGC149659
Molecular Weight
Mass (kDA):
16.453 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (39731255..39738029, complement) |
Tissue Specificity
Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasmic granule. Localized in granules from where it may be secreted or transported to other locations in the cell.
Diseases
- Leukemia
- Pain
- Neoplasms
- Malignant Neoplasms
- Inflammation
- Bartter Disease
- Dent's Disease
- Nervousness
- Diabetes Mellitus
- Pain, Postoperative
- Fibrosis
- Carcinoma
- Kidney Calculi
Pathways
- Transport
- Localization
- Endocytosis
- Secretion
- Chloride Transport
- Pathogenesis
- Transepithelial Transport
- Antiport
- Proton Transport
- Virulence
- Ion Transport
- Receptor-mediated Endocytosis
- Cell Division
PTMs
- Phosphorylation
- Nitration
- Cleavage
- Oxidation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLC
bosterbio.com/bosterbio-gene-info-cards/CLC
References
PMID: 8419478 by Ackerman S.J., et al. Molecular cloning and characterization of human eosinophil Charcot- Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily.
PMID: 9119387 by Dyer K.D., et al. The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes.