Cyclic GMP-AMP synthase Antibodies

AND CGAS ELISA kits, Cyclic GMP-AMP synthase Proteins

Many biological assays use antibodies to detect Cyclic GMP-AMP synthase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclic GMP-AMP synthase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclic GMP-AMP synthase antibodies...

We validate the specificity of these antibodies to Cyclic GMP-AMP synthase by testing them on tissues known to express CGAS positively and negatively. Browse below to find the CGAS antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: NT5C3B

CGAS Infographic by Boster Bio

All CGAS Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MB21D1 CGAS Antibody

Human

ELISA, IHC, WB

$405
Cat # A31676
100ul

Anti-CGAS Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A31676-1
100 μg/vial

C6orf150 (MB21D1) (NM_138441) Human Over-expression Lysate

Human

$960
Cat # LS115004
100 µg

CGAS Overview

Facts about Cyclic GMP-AMP synthase.

CGAS 3D structure. Source: alphafold

Cyclic GMP-AMP synthase (CGAS)

Catalysis involves the creation of a 2',5' phosphodiester linkage at the GpA step and the creation of a 3',5' phosphodiester linkage at the ApG step, generating c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune reactions (PubMed:28363908).

Binds cytosolic DNA directly, resulting in activation and synthesis of cGAMP, another messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Also functions as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945).

Gene Information

Human
Gene Name:	CGAS
Uniprot:	Q8N884
Entrez:	115004

Family

Belongs to:

mab-21 family

Alternative Names

Cyclic GMP-AMP synthase

Molecular Weight

Mass (kDA):
58.814 kDA

Genomic Context


Human

Location:	6q13
Sequence:	6; NC_000006.12 (73423711..73452297, complement)

Tissue Specificity

Expressed in the monocytic cell line THP1.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Nucleus. In resting conditions, localizes at the cell membrane as a peripheral membrane protein by binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (PubMed:30827685). Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubMed:26

PTMs

Acetylation

Isopeptide bond

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CGAS

References

PMID: 23258413 by Sun L., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

PMID: 21478870 by Schoggins J.W., et al. A diverse range of gene products are effectors of the type I interferon antiviral response.