CCDC65 Antibodies

AND CCDC65 ELISA kits, CCDC65 Proteins

Many biological assays use antibodies to detect CCDC65, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCDC65 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCDC65 antibodies...

We validate the specificity of these antibodies to CCDC65 by testing them on tissues known to express CCDC65 positively and negatively. Browse below to find the CCDC65 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCDC65 Infographic by Boster Bio

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CCDC65 (NM_033124) Human Over-expression Lysate

Human

$628
Cat # LS085478
100 µg

CCDC65 Overview

Facts about Dynein regulatory complex subunit 2.

CCDC65 3D structure. Source: alphafold

Dynein regulatory complex subunit 2 (CCDC65)

Part of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary/flagellar motility which preserves the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a crucial role in the assembly of N-DRC and stabilizes the assembly of numerous inner dynein arms and radial spokes.

Coassembles with DRC1 to form a central scaffold required for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744). .

Gene Information

Human
Gene Name:	CCDC65
Uniprot:	Q8IXS2
Entrez:	85478

Family

Belongs to:

DRC2 family

Alternative Names

coiled-coil domain containing 65; coiled-coil domain-containing protein 65; FLJ25663; FLJ35732; NYD-SP28; Testis development protein NYD-SP28

Molecular Weight

Mass (kDA):
57.297 kDA

Genomic Context


Human

Location:	12q13.12
Sequence:	12; NC_000012.12 (48904133..48921576)

Tissue Specificity

Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.

Diseases

Liver Carcinoma
Liver Neoplasms

Pathways

Sperm Capacitation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCDC65

References

PMID: 17089017 by Zheng Y., et al. Cloning and characterization of a novel sperm tail protein, NYD- SP28.

PMID: 24094744 by Austin-Tse C., et al. Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia.