This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Caspase-8 Antibodies
AND CASP8 ELISA kits, Caspase-8 Proteins
Many biological assays use antibodies to detect Caspase-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-8 antibodies...
Previous: BFSP1
Next: CASQ1
CASP8 Infographic by Boster Bio
All CASP8 Products
Product
Figures
Specificity
Applications
Price
Human Caspase 8/CASP8 ELISA Kit PicoKine®
1 Citations 8 Q&As
Human
ELISA
$750
Cat # EK1426
96 wells/kit, with removable strips.
Cat # EK1426
96 wells/kit, with removable strips.
Anti-Caspase-8 (P18)/CASP8 Antibody Picoband®
17 Citations 16 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1308
100 μg/vial
Cat # PA1308
100 μg/vial
Anti-Caspase-8(P10)/CASP8 Antibody Picoband®
17 Citations 5 Q&As
Human
IHC, WB
$370
Cat # PA1524
100 μg/vial
Cat # PA1524
100 μg/vial
Anti-Caspase-8(p18)/CASP8 Antibody Picoband®
16 Citations 17 Q&As
Human
IHC, WB
$370
Cat # PA1735
100 μg/vial
Cat # PA1735
100 μg/vial
Anti-Caspase-8 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human
IF, ICC, WB
$370
Cat # M00042-2
100 μl
Cat # M00042-2
100 μl
Anti-Caspase-8 CASP8 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00042-1
100 μl
Cat # M00042-1
100 μl
Anti-Caspase 8/CASP8 Antibody Picoband®
8 Citations 16 Q&As
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00042-1
100 μg/vial
Cat # A00042-1
100 μg/vial
Anti-Caspase-8 Monoclonal Antibody (5F7)
3 Citations 15 Q&As
Human
IP, IHC, WB
$576
Cat # M00042-3
100µg
Cat # M00042-3
100µg
Human, Mouse, Rat
ELISA
$480
Cat # EKC1088
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1088
1 kit, containing one 96-well plate and all necessary reagents
Human, Rat
ELISA
$540
Cat # EKC1976
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1976
1 kit, containing two 96-well plates and all necessary reagents
Anti-Caspase 8/CASP8 Antibody Picoband®
31 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A00042
100 μg/vial
Cat # A00042
100 μg/vial
Anti-Caspase-8/CASP8 Antibody Picoband®
3 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00042-3
100 μg/vial
Cat # A00042-3
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$449
Cat # A00042-4
0.1 mg
Cat # A00042-4
0.1 mg
CASP8 Overview
Facts about Caspase-8.
Caspase-8 (CASP8)
Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation.
The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASP8 |
| Uniprot: | Q14790 |
| Entrez: | 841 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy
Molecular Weight
Mass (kDA):
55.391 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1 |
| Sequence: | 2; NC_000002.12 (201233443..201287711) |
Tissue Specificity
Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Inflammation
- Neuroblastoma
- Lymphoma
- Malignant Tumor Of Colon
- Adenocarcinoma
- Prostatic Neoplasms
Interacting Proteins
- AR
- BCAP31
- CASP10
- CASP8AP2
- CFLAR
- CUL3
- FADD
- FAS
- FASLG
- ILK
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Pathogenesis
- Programmed Cell Death
- Cell Proliferation
- Methylation
- Sensitization
- Cell Growth
- Localization
- Release Of Cytochrome C From Mitochondria
- Apoptotic Process
- Proteolysis
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Dephosphorylation
- Demethylation
- Acetylation
- Ubiquitination
- Reduction
- Oxidation
- Nitrosylation
Research Areas
- Apoptosis
- Apoptosis Detections
- Cancer
- Caspases
- Cell Biology
- Phospho-Specific
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP8
bosterbio.com/bosterbio-gene-info-cards/CASP8
References
PMID: 8681376 by Boldin M.P., et al. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
PMID: 8681377 by Muzio M., et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex.
43 Publications of Boster Caspase-8 Antibodies & ELISA Kits
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: 10.3892/or.2017.5395, Calcium release induced by 2-pyridinecarboxaldehyde thiosemicarbazone and its co...
- PubMed ID: 10.3892/or.2015.4530, Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine ...
- PubMed ID: 10.3892/ijo.2017.4149, Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate part...
- PubMed ID: 10.3892/ijo.2017.4148, Effects of baicalein on proliferation, apoptosis, migration and invasion of Ewin...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.1248/bpb.b13-00794, Involvement of substance P/neurokinin-1 receptor in the analgesic and anticancer...
- PubMed ID: 10.1186/s12985-017-0852-z, Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits t...
- PubMed ID: 10.1177/1934578X1200700826, Muscone Exerts Neuroprotection in an Experimental Model of Stroke via Inhibition...
- PubMed ID: 10.1155/2021/5594059, Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, ...
- PubMed ID: 10.1142/S0192415X15500299, Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice
- PubMed ID: 10.1111/dth.14720, CD4+T cells apoptosis and conversion of Th1/Th2‐type cytokines promote the pro...
- PubMed ID: 10.1039/C5TB00514K, Design of magnetic nanoparticles for hepatocellular carcinoma treatment using th...
- PubMed ID: 10.1038/aja.2009.87, Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in ...
- PubMed ID: 10.1016/j.toxicon.2009.01.035, Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells o...
- PubMed ID: 10.1016/j.tiv.2007.04.008, A cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via F...
- PubMed ID: 10.1016/j.taap.2010.02.004, The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is ...
- PubMed ID: 10.1016/j.jep.2008.10.042, Total saponins of Panax Notoginseng modulate the expression of caspases and atte...
- PubMed ID: 10.1016/j.bbrc.2005.03.182, Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human...
- PubMed ID: , Pathway of programmed cell death in HeLa cells induced by polymeric anti-cancer ...
- PubMed ID: , Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobil...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page