This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
BRDT Antibodies
AND BRDT ELISA kits, BRDT Proteins
Many biological assays use antibodies to detect BRDT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRDT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRDT antibodies...
Previous: BFSP1
Next: ZFP36L1
BRDT Infographic by Boster Bio
All BRDT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A04985-2
100 μg/vial
Cat # A04985-2
100 μg/vial
BRDT Overview
Facts about Bromodomain testis-specific protein.
Bromodomain testis-specific protein (BRDT)
Testis-specific chromatin protein which specifically binds histone H4 acetylated at'Lys-5' and'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones in the promoter of specific meiotic and post-meiotic genes, facilitating their activation in the suitable time (PubMed:22901802).
In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their overall removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated in'Lys-8' (H4K8ac), although it's unable to bind H4 butyrylated in'Lys-5' (H4K5ac) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | BRDT |
| Uniprot: | Q58F21 |
| Entrez: | 676 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bromodomain testis-specific protein; bromodomain, testis-specific; Cancer/testis antigen 9; CT9BRD6; RING3-like protein
Molecular Weight
Mass (kDA):
107.954 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.1 |
| Sequence: | 1; NC_000001.11 (91949371..92014428) |
Tissue Specificity
Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.
Subcellular Localizations
Nucleus. Detected on chromatin.
Diseases
- Male Infertility
- Infertility
- Malignant Neoplasms
- Carcinoma
- Neoplasms
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Lung
- Azoospermia
- Adenocarcinoma
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Cholangiocarcinoma
- Melanoma
Pathways
- Spermatogenesis
- Histone Acetylation
- Meiosis
- Chromatin Remodeling
- Localization
- Methylation
- Dna Packaging
- Diplotene
- Reverse Transcription
- Cell Differentiation
- Mitosis
- Fertilization
- Sperm Chromatin Condensation
PTMs
- Acetylation
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRDT
bosterbio.com/bosterbio-gene-info-cards/BRDT
References
PMID: 9367677 by Jones M.H., et al. Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.
PMID: 15647849 by Zheng Y., et al. Molecular cloning and expression of a novel alternative splice variant of BRDT gene.