Bestrophin-1 Antibodies

AND BEST1 ELISA kits, Bestrophin-1 Proteins

Many biological assays use antibodies to detect Bestrophin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bestrophin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bestrophin-1 antibodies...

We validate the specificity of these antibodies to Bestrophin-1 by testing them on tissues known to express BEST1 positively and negatively. Browse below to find the BEST1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BEST1 Infographic by Boster Bio

All BEST1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Bestrophin/BEST1 Antibody Picoband®

Human

Flow Cytometry, IHC, ICC, WB

$370
Cat # A01434-1
100 μg/vial

Anti-Human Bestrophin DyLight® 488 conjugated BEST1 Antibody

Human

Flow Cytometry

$515
Cat # A01434-Dyl488
100 μg/vial

Anti-Human Bestrophin DyLight® 550 conjugated BEST1 Antibody

6 Q&As

Human

Flow Cytometry

$515
Cat # A01434-Dyl550
100 μg/vial

Human BEST1 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTO76090
Starting from 20ug

Bestrophin (BEST1) (NM_004183) Human Over-expression Lysate

Human

$960
Cat # LS007439
100 µg

Anti-Bestrophin-1/Best1 Antibody Picoband®

Mouse, Rat

ELISA, WB

$370
Cat # A01434-2
100 µg/vial

BEST1 Overview

Facts about Bestrophin-1.

BEST1 3D structure. Source: alphafold

Bestrophin-1 (BEST1)

Types calcium-sensitive chloride channels. Highly permeable to bicarbonate.

Gene Information

Human
Gene Name:	BEST1
Uniprot:	O76090
Entrez:	7439

Family

Belongs to:

bestrophin family

Alternative Names

ARB; Best disease; BEST; bestrophin 1; bestrophin-1; BMD; TU15B; vitelliform macular dystrophy 2; Vitelliform macular dystrophy protein 2; VMD2RP50

Molecular Weight

Mass (kDA):
67.684 kDA

Genomic Context


Human

Location:	11q12.3
Sequence:	11; NC_000011.10 (61946722..61965515)

Tissue Specificity

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.

Diseases

Age Related Macular Degeneration
Vitelliform Macular Dystrophy
Dystrophy
Retinal Diseases
Retinal Degeneration
Hereditary Corneal Dystrophy
Retinal Dystrophies
Fibrosis
Macule
Maculopathy
Pathologic Neovascularization
Cystic Fibrosis

Choroidal Neovascularization
Abnormal Degeneration
Visual Impairment
Atrophy
Adult-onset Vitelliform Macular Dystrophy
Vitreoretinochoroidopathy (disorder)
Retinitis Pigmentosa

Pathways

Transport
Localization
Secretion
Pathogenesis
Phagocytosis
Cell Proliferation
Ion Transport
Fluid Transport
Chloride Transport
Cellular Localization
Rna Interference
Cell Adhesion
Protein Phosphorylation

Pigment Accumulation
Pigmentation
Mrna Splicing
Translation
Cell Cycle
Cell Differentiation
Segmentation

PTMs

Phosphorylation

Dephosphorylation

Biotinylation

Research Areas

Neuroscience
Sensory Systems
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BEST1

References

PMID: 9700209 by Marquardt A., et al. Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).

PMID: 9662395 by Petrukhin K., et al. Identification of the gene responsible for Best macular dystrophy.