B3GNT6 Antibodies

AND B3GNT6 ELISA kits, B3GNT6 Proteins

Many biological assays use antibodies to detect B3GNT6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B3GNT6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B3GNT6 antibodies...

We validate the specificity of these antibodies to B3GNT6 by testing them on tissues known to express B3GNT6 positively and negatively. Browse below to find the B3GNT6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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B3GNT6 Infographic by Boster Bio

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B3GNT6 (NM_138706) Human Over-expression Lysate

Human

$628
Cat # LS192134
100 µg

B3GNT6 Overview

Facts about Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase.

B3GNT6 3D structure. Source: alphafold

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6)

Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of this O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.

Gene Information

Human
Gene Name:	B3GNT6
Uniprot:	Q6ZMB0
Entrez:	192134

Family

Belongs to:

glycosyltransferase 31 family

Alternative Names

B3GNT6; B3Gn-T6; beta-1,3-Gn-T6; Beta-1,3-N-acetylglucosaminyltransferase 6; beta-1,3-N-acetylglucosaminyltransferase protein; Beta3Gn-T6; BGnT-6; Core 3 synthase; EC 2.4.1.-; IMAGE:4907098; MGC119334; MGC119336; MGC119337; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase); UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

Molecular Weight

Mass (kDA):
42.748 kDA

Genomic Context


Human

Location:	11q13.5
Sequence:	11; NC_000011.10 (77034398..77041973)

Tissue Specificity

Present in stomach and colon (at protein level). Restricted in the stomach, colon and small intestine, where core 3 structure is present.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Classical Galactosemia
Fibrosarcoma
Udpglucose 4-epimerase Deficiency Disease
Renal Fibrosarcoma

Pathways

Transport
Protein Glycosylation
Glycosylation

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/B3GNT6

References

PMID: 11821425 by Iwai T., et al. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.

PMID: 7655172 by Vavasseur F., et al. Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc- R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.