B3GNT5 Antibodies

AND B3GNT5 ELISA kits, B3GNT5 Proteins

Many biological assays use antibodies to detect B3GNT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B3GNT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B3GNT5 antibodies...

We validate the specificity of these antibodies to B3GNT5 by testing them on tissues known to express B3GNT5 positively and negatively. Browse below to find the B3GNT5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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B3GNT5 Infographic by Boster Bio

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B3GNT5 (NM_032047) Human Over-expression Lysate

Human

$628
Cat # LS084002
100 µg

B3GNT5 Overview

Facts about Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase.

B3GNT5 3D structure. Source: alphafold

Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)

Beta-1,3-N-acetylglucosaminyltransferase that plays an integral role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, especially by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively.

Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. .

Gene Information

Human
Gene Name:	B3GNT5
Uniprot:	Q9BYG0
Entrez:	84002

Family

Belongs to:

glycosyltransferase 31 family

Alternative Names

B3GN-T5; beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase; beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-N-acetylglucosaminyltransferase bGnT-5; beta3Gn-T5; BGnT-5; EC 2.4.1; EC 2.4.1.-; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Molecular Weight

Mass (kDA):
44.053 kDA

Genomic Context


Human

Location:	3q27.1
Sequence:	3; NC_000003.12 (183253207..183273391)

Tissue Specificity

Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Swine Diseases
Escherichia Coli Infections
Tissue Adhesions
Growth Retardation
Neoplasms
Embryonal Carcinoma
Obesity
Glioblastoma

Diarrhea
Carcinoma

Pathways

Cell Adhesion
Methylation
Cell Activation
Coagulation
Cell Differentiation
Hatching
Dna Methylation

Glycosylation
B Cell Activation

PTMs

Phosphorylation

Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/B3GNT5

References

PMID: 11283017 by Togayachi A., et al. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.

PMID: 11384981 by Henion T.R., et al. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis.