This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
1 Citations 17 Q&As
Facts about Disintegrin and metalloproteinase domain-containing protein 17.
Responsible for the proteolytic release of several other cell-surface proteins, such as p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Human | |
---|---|
Gene Name: | ADAM17 |
Uniprot: | P78536 |
Entrez: | 6868 |
Belongs to: |
---|
No superfamily |
ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; ADAM17; ADAM18; CD156b antigen; CD156b; CSVP; disintegrin and metalloproteinase domain-containing protein 17; EC 3.4.24.86; MGC71942; Snake venom-like protease; TACE; TACEcSVP; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Mass (kDA):
93.021 kDA
Human | |
---|---|
Location: | 2p25.1 |
Sequence: | 2; NC_000002.12 (9488486..9555830, complement) |
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Membrane; Single-pass type I membrane protein.
PMID: 9034191 by Moss M.L., et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
PMID: 9034190 by Black R.A., et al. A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells.
*More publications can be found for each product on its corresponding product page