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ATG14 Antibodies
AND ATG14 ELISA kits, ATG14 Proteins
Many biological assays use antibodies to detect ATG14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATG14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATG14 antibodies...
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ATG14 Infographic by Boster Bio
All ATG14 Products
Product
Figures
Specificity
Applications
Price
Anti-ATG14L Antibody Picoband®
1 Citations 17 Q&As
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9481
100 μg/vial
Cat # PB9481
100 μg/vial
ATG14 Overview
Facts about Beclin 1-associated autophagy-related key regulator.
Beclin 1-associated autophagy-related key regulator (ATG14)
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complicated PI3KC3-C1 (PubMed:18843052, PubMed:19050071).
Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi system to autophagosomes (PubMed:20713597).
Gene Information
| Human | |
|---|---|
| Gene Name: | ATG14 |
| Uniprot: | Q6ZNE5 |
| Entrez: | 22863 |
Family
| Belongs to: |
|---|
| ATG14 family |
Alternative Names
ATG14 Autophagy Related 14 Homolog (S. Cerevisiae); ATG14 Autophagy Related 14 Homolog; ATG14L; Autophagy Related 14; Autophagy-Related Protein 14-Like Protein; Barkor; Beclin 1-Associated Autophagy-Related Key Regulator; Beclin 1-interacting protein; KIAA0831
Molecular Weight
Mass (kDA):
55.309 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q22.3 |
| Sequence: | 14; NC_000014.9 (55366391..55411830, complement) |
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By simil
Diseases
- Neoplasms
- Salmonella Infections
- Cell Invasion
- Osteosarcoma
- Metabolic Diseases
- Malnutrition
- Malignant Neoplasms
- Muscular Atrophy
Interacting Proteins
- BECN1
- PIK3C3
Pathways
- Autophagy
- Macroautophagy
- Localization
- Response To Nutrient
- Transport
- Regulation Of Macroautophagy
- Aging
- Endocytosis
- Energy Homeostasis
- Muscle Atrophy
- Cellular Response To Nutrient
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATG14
bosterbio.com/bosterbio-gene-info-cards/ATG14
References
PMID: 18843052 by Itakura E., et al. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
PMID: 19050071 by Sun Q., et al. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
1 Publications of Boster ATG14 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s11418-020-01399-5, Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarc...
*More publications can be found for each product on its corresponding product page