Acetyl-CoA carboxylase 2 Antibodies

AND ACACB ELISA kits, Acetyl-CoA carboxylase 2 Proteins

Many biological assays use antibodies to detect Acetyl-CoA carboxylase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acetyl-CoA carboxylase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acetyl-CoA carboxylase 2 antibodies...

We validate the specificity of these antibodies to Acetyl-CoA carboxylase 2 by testing them on tissues known to express ACACB positively and negatively. Browse below to find the ACACB antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACACB Infographic by Boster Bio

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Anti-Acetyl Coenzyme A Carboxylase/ACACB Antibody Picoband®

1 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # A03668-2
100 μg/vial

ACACB Overview

Facts about Acetyl-CoA carboxylase 2.

ACACB 3D structure. Source: alphafold

Acetyl-CoA carboxylase 2 (ACACB)

Catalyzes the ATP-dependent carboxylation of acetyl-CoA into malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).

Gene Information

Human
Gene Name:	ACACB
Uniprot:	O00763
Entrez:	32

Family

Belongs to:

No superfamily

Alternative Names

ACC2ACC-beta; ACCBacetyl-CoA carboxylase 2; acetyl-CoA carboxylase beta; acetyl-Coenzyme A carboxylase beta; EC 6.4.1.2; HACC275

Molecular Weight

Mass (kDA):
276.541 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (109112666..109268226)

Tissue Specificity

Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).

Subcellular Localizations

Mitochondrion.

Diseases

Diabetes Mellitus
Obesity
Diabetes Mellitus, Non-insulin-dependent
Insulin Resistance
Insulin Sensitivity
Steatohepatitis
Steatosis
Fatty Liver
Kidney Diseases
Diabetic Nephropathy
Inflammation
Malignant Neoplasms
Neoplasms

Dysequilibrium Syndrome
Liver Carcinoma
Hypercholesterolemia
Hypertrophy
Liver Diseases
Nonalcoholic Fatty Liver Disease
Cholangiocarcinoma

Interacting Proteins

HLCS
Mid1ip1

Pathways

Fatty Acid Oxidation
Pathogenesis
Glycolysis
Secretion
Muscle Contraction
Gluconeogenesis
Glucose Homeostasis
Cell Proliferation
Fatty Acid Beta-oxidation
Lipid Oxidation
Transport
Hibernation
Cell Activation

Aging
Protein Secretion
Keratinocyte Differentiation
Urea Cycle
Reverse Transcription
Translation
Regulation Of Fatty Acid Oxidation

PTMs

Oxidation
Phosphorylation

Carboxylation
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACACB

References

PMID: 9099716 by Abu-Elheiga L., et al. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

PMID: 16854592 by Cheng D., et al. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.