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PARK7 Antibodies
AND PARK7 ELISA kits, PARK7 Proteins
Many biological assays use antibodies to detect PARK7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARK7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARK7 antibodies...
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PARK7 Infographic by Boster Bio
All PARK7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PB9308
100 μg/vial
Cat # PB9308
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00757
100 μl
Cat # M00757
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1171
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1171
1 kit, containing one 96-well plate and all necessary reagents
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00757-4
100 μg/vial
Cat # M00757-4
100 μg/vial
PARK7 Overview
Facts about Protein/nucleic acid deglycase DJ-1.
Protein/nucleic acid deglycase DJ-1 (PARK7)
Protein and nucleotide deglycase which catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.
Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087).
Gene Information
| Human | |
|---|---|
| Gene Name: | PARK7 |
| Uniprot: | Q99497 |
| Entrez: | 11315 |
Family
| Belongs to: |
|---|
| peptidase C56 family |
Alternative Names
DJ1; DJ-1; DJ1FLJ34360; EC 3.4; FLJ27376; FLJ92274; Oncogene DJ1; Park7; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; protein DJ-1
Molecular Weight
Mass (kDA):
19.891 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.23 |
| Sequence: | 1; NC_000001.11 (7961654..7985505) |
Tissue Specificity
Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253).
Subcellular Localizations
Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Endoplasmic reticulum. Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation.
Diseases
- Parkinson Disease
- Secondary Parkinson Disease
- Neurodegenerative Disorders
- Malignant Neoplasms
- Neoplasms
- Nerve Degeneration
- Neuroblastoma
- Alzheimer's Disease
- Movement Disorders
- Carcinoma
- Dementia
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
Interacting Proteins
- AR
- DAXX
- FADD
- GOPC
- MTA2
- OTUD7B
- PYCR1
- RACK1
Pathways
- Pathogenesis
- Cell Death
- Localization
- Autophagy
- Response To Oxidative Stress
- Neuroprotection
- Transport
- Aging
- Secretion
- Cell Proliferation
- Fertilization
- Protein Folding
- Electron Transport
PTMs
- Oxidation
- Phosphorylation
- Sumoylation
- Ubiquitination
- Cleavage
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- DNA replication, Transcription, Translation and Splicing
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARK7
bosterbio.com/bosterbio-gene-info-cards/PARK7
References
PMID: 9070310 by Nagakubo D., et al. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.
PMID: 11223268 by Taira T., et al. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.