Anti-PACE4/PCSK6 Antibody Picoband®

Product Name

Anti-PACE4/PCSK6 Antibody Picoband®

View all PACE4/PCSK6 Antibodies

SKU/Catalog Number

PB9769

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-PACE4/PCSK6 Antibody Picoband® catalog # PB9769. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PACE4/PCSK6 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9769)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PACE4, different from the related rat sequence by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9769 is reactive to PCSK6 in Human, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

80 kDa, 45/80/100 kDa

Calculated molecular weight

106420 MW

Background of PACE4/PCSK6

Proprotein convertase subtilisin/kexin type 6 is an enzyme that in humans is encoded by the PCSK6 gene. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PB9769 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat

Positive Control

WB: Rat Brain Tissue, 293T Whole Cell

Validation Images & Assay Conditions

Gene/Protein Information For PCSK6 (Source: Uniprot.org, NCBI)

Alternative Names

Proprotein convertase subtilisin/kexin type 6;3.4.21.-;Paired basic amino acid cleaving enzyme 4;Subtilisin-like proprotein convertase 4;SPC4;Subtilisin/kexin-like protease PACE4;PCSK6;PACE4; PCSK6 PACE4, SPC4 proprotein convertase subtilisin/kexin type 6 proprotein convertase subtilisin/kexin type 6|paired basic amino acid cleaving enzyme 4|paired basic amino acid cleaving system 4|subtilisin-like proprotein convertase 4|subtilisin/kexin-like protease PACE4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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