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Product Info Summary
| SKU: | A00619 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Melanocortin receptor 4 MC4R Antibody
View all Melanocortin-4 R Antibodies
SKU/Catalog Number
A00619
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Melanocortin receptor 4 MC4R Antibody (Catalog # A00619). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
MC4R antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Melanocortin receptor 4 MC4R Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00619)
Host
Rabbit
Contents
MC4R Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
MC4R antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MC4R. The immunogen is located within the first 50 amino acids of MC4R.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.
Reactive Species
A00619 is reactive to MC4R in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
36943 MW
Background of Melanocortin-4 R
The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00619 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MC4R antibody can be used for detection of MC4R by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 μg/mL.
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Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For MC4R (Source: Uniprot.org, NCBI)
Gene Name
MC4R
Full Name
Melanocortin receptor 4
Weight
36943 MW
Superfamily
G-protein coupled receptor 1 family
Alternative Names
Melanocortin receptor 4, MC4-R MC4R BMIQ20 melanocortin 4 receptor melanocortin receptor 4|MC4-R
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MC4R, check out the MC4R Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MC4R: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Melanocortin receptor 4 MC4R Antibody (A00619)
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