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Product Info Summary
| SKU: | A15486 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CCDC141 Antibody
SKU/Catalog Number
A15486
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CCDC141 Antibody (Catalog # A15486). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
CCDC141 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CCDC141 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15486)
Host
Rabbit
Contents
CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141. The immunogen is located within amino acids 40 - 90 of CCDC141.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of CCDC141 are known to exist.
Reactive Species
A15486 is reactive to CCDC141 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
166261 MW
Background of CCDC141
Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A15486 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CCDC141 in SK-N-SH cell tissue lysate with CCDC141 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide
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Immunohistochemistry of CCDC141 in mouse brain tissue with CCDC141 antibody at 5 μg/mL.
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Immunofluorescence of CCDC141 in mouse brain tissue with CCDC141 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CCDC141 (Source: Uniprot.org, NCBI)
Gene Name
CCDC141
Full Name
Coiled-coil domain-containing protein 141
Weight
166261 MW
Alternative Names
CAMDI, Coiled-coil domain-containing protein 141 CCDC141 CAMDI coiled-coil domain containing 141 coiled-coil domain-containing protein 141|coiled-coil protein associated with myosin II and DISC1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CCDC141, check out the CCDC141 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CCDC141: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CCDC141 Antibody (A15486)
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