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Bcl-2-like protein 1 Antibodies
AND BCL2L1 ELISA kits, Bcl-2-like protein 1 Proteins
Many biological assays use antibodies to detect Bcl-2-like protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bcl-2-like protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bcl-2-like protein 1 antibodies...
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BCL2L1 Infographic by Boster Bio
All BCL2L1 Products
Product
Figures
Specificity
Applications
Price
Anti-Bcl-X/BCL2L1 Antibody Picoband®
5 Citations 16 Q&As
Human
Flow Cytometry, IHC, ICC, WB
$370
Cat # PB9917
100 μg/vial
Cat # PB9917
100 μg/vial
Anti-Bcl-XS/BCL2L1 Antibody Picoband®
10 Citations 17 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1232
100 μg/vial
Cat # PA1232
100 μg/vial
Anti-Bcl-XL/BCL2L1 Antibody Picoband®
6 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A00181
100 μg/vial
Cat # A00181
100 μg/vial
Anti-Bcl-XL BCL2L1 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00181-1
100 μl
Cat # M00181-1
100 μl
Anti-Human Bcl-XL DyLight® 488 conjugated BCL2L1 Antibody
3 Citations 14 Q&As
Human
Flow Cytometry
$515
Cat # A00181-Dyl488
100 μg/vial
Cat # A00181-Dyl488
100 μg/vial
Anti-Human Bcl-XL DyLight® 550 conjugated BCL2L1 Antibody
1 Citations 14 Q&As
Human
Flow Cytometry
$515
Cat # A00181-Dyl550
100 μg/vial
Cat # A00181-Dyl550
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1057
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1057
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2190
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2190
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2364
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2364
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00181T47-1
100ul
Cat # A00181T47-1
100ul
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00181-3
100 µl/vial
Cat # M00181-3
100 µl/vial
BCL2L1 Overview
Facts about Bcl-2-like protein 1.
Bcl-2-like protein 1 (BCL2L1)
Potent inhibitor of cell death. Inhibits activation of caspases.
Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also functions as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | BCL2L1 |
| Uniprot: | Q07817 |
| Entrez: | 598 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
Apoptosis regulator Bcl-X; bcl2-L-1; BCL2-like 1; bcl-2-like protein 1; BCLXBCL2LBcl-X; BclxL; Bcl-xL; BCL-XL/S; BCLXS; bcl-xS; DKFZp781P2092
Molecular Weight
Mass (kDA):
26.049 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (31664452..31723963, complement) |
Tissue Specificity
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Subcellular Localizations
[Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Lymphoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Myeloid Leukemia
- Adenocarcinoma
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
Interacting Proteins
- BAD
- Bad
- BAK1
- BAX
- BBC3
- Bbc3
- BCL2L11
- BECN1
- BID
- BIK
Pathways
- Cell Death
- Cell Cycle
- Induction Of Apoptosis
- Programmed Cell Death
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Localization
- Cell Cycle Arrest
- Drug Resistance
- Apoptotic Process
- Secretion
- Sensitization
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
- Phosphorothioation
- Reduction
- Deamidation
- Ubiquitination
- Acetylation
- Methylation
- Oxidation
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL2L1
bosterbio.com/bosterbio-gene-info-cards/BCL2L1
References
PMID: 8358789 by Boise L.H., et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
PMID: 9675101 by Ban J., et al. Identification of a human cDNA encoding a novel Bcl-x isoform.
15 Publications of Boster Bcl-2-like protein 1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.2016.4625, The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogene...
- PubMed ID: 10.3390/i7020059, Downregulation of the Expression of GLUT1 Plays a Role in Apoptosis Induced by S...
- PubMed ID: 10.1016/j.transproceed.2006.06.008, Comparison of Rapamycin Versus FK506 on Expression of Cytoprotective Genes in th...
- PubMed ID: 10.1016/j.transproceed.2006.06.007, Conversion From Cyclosporine to Mycophenolate Mofetil Improves Expression of A20...
- PubMed ID: 10.1016/j.phymed.2016.04.001, The natural secolignan peperomin E induces apoptosis of human gastric carcinoma ...
- PubMed ID: 10.1016/j.lfs.2006.12.024, ACTX-8, a cytotoxic l-amino acid oxidase isolated from Agkistrodon acutus snake ...
- PubMed ID: 10.1002/ar.21317, Protective Effect of Quercetin on Cadmium‐Induced Oxidative Toxicity on Germ C...
- PubMed ID: 10.1002/ar.21317, Protective Effect of Quercetin on Cadmium‐Induced Oxidative Toxicity on Germ C...
- PubMed ID: 10.1002/ar.21317, Protective Effect of Quercetin on Cadmium‐Induced Oxidative Toxicity on Germ C...
- PubMed ID: 33382670, Chen H,Sheng H,Zhao Y,Zhu G.Piperine Inhibits Cell Proliferation and Induces Apo...
- PubMed ID: 12439908, Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma...
- PubMed ID: 28849044, Emodin alleviates severe acute pancreatitis-associated acute lung injury by decr...
- PubMed ID: 28731164, Guo X, Guo N, Zhao J, Cai Y. Oncol Rep. 2017 Sep;38(3):1442-1450. doi: 10.3892/o...
- PubMed ID: 29541349, Liu X, Lin X, Mi Y, Li J, Zhang C. Oxid Med Cell Longev. 2018 Jan 9;2018:9390810...
- PubMed ID: 24213508, Zhou X, Zhang Y, Li Y, Hao X, Liu X, Wang Y. Cancers (Basel). 2012 Dec 4;4(4):13...
*More publications can be found for each product on its corresponding product page