Anti-Activin Receptor Type IIB/ACVR2B Antibody Picoband®

Product Name

Anti-Activin Receptor Type IIB/ACVR2B Antibody Picoband®

View all Activin RIIB Antibodies

SKU/Catalog Number

PB9975

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Activin Receptor Type IIB/ACVR2B Antibody Picoband® catalog # PB9975. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Activin Receptor Type IIB/ACVR2B Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9975)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ACVR2B, identical to the related mouse and rat sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9975 is reactive to ACVR2B in Human, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

55 kDa

Calculated molecular weight

57724 MW

Background of Activin RIIB

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This ACVR2B gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PB9975 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat

Positive Control

WB: rat skeletal muscle tissue, MCF-7 whole cell

Validation Images & Assay Conditions

Gene/Protein Information For ACVR2B (Source: Uniprot.org, NCBI)

Alternative Names

Activin receptor type-2B;2.7.11.30;Activin receptor type IIB;ACTR-IIB;ACVR2B; ACVR2B ACTRIIB, ActR-IIB, HTX4 activin A receptor type 2B activin receptor type-2B|activin A receptor, type IIB

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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